NUCLEOSIDE AND NUCLEOTIDE REVERSE TRANSCRIPTASE INHIBITORS

	Nucleoside and Nucleotide reverse transcriptase inhibitors		Protease inhibitors
	Non-Nucleoside reverse transcriptase inhibitors		Fusion inhibitors
	HIV-2

	Mutations associated to resistance	Mutations associated to « possible resistance »
ZDV	T215Y/F At least 3 mutations among : M41L, D67N, K70R, L210W, T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [1, 2, 3, 4] Q151M Insertion at codon 69	T215A/C/D/E/G/H/I/L/N/S/V [1, 2, 3, 4]
3TC/FTC	M184V/I Insertion at codon 69	K65R [11, 12, 16] Q151M
ddI	At least a score of + 2 among: M41L + T69D + L74V + T215Y/F + K219Q/E – K70R – M184 V/I [5, 14, 15, 17, 18] L74V without any mutations among M41L, T69D, K70R, M184 V/I, T215Y/F, K219Q/E [19] Q151M Insertion at codon 69	K65R [11, 12]
d4T	V75M/S/A/T T215Y/F [6] At least 3 mutations among : M41L, D67N, K70R, L210W, T215A/C/D/E/G/H/I/L/N/S/V, K219Q/E [4, 7, 14, 15] Q151M Insertion at codon 69	T215A/C/D/E/G/H/I/L/N/S/V [4, 7]
ABC	At least 5 mutations among : M41L, D67N, L74V, M184V/I, L210W, T215Y/F [8, 19] K65R and L74V and Y115F and M184V/I Q151M Insertion at codon 69	4 mutations among : M41L, D67N, L74V, M184V/I, L210W, T215Y/F [8, 19] K65R [9, 11, 12]
TDF	At least 6 mutations among: M41L, E44D, D67N, T69D/N/S, L74V, L210W, T215Y/F [13, 20] K65R [9, 10, 11, 12] Insertion at codon 69	3, 4 or 5 mutations among: : M41L, E44D, D67N, T69D/N/S, L74V, L210W, T215Y/F [13] K70E [21, 22, 23]